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I went through my collection... In general, I have at least one of each bronze and silver card, and I've already disenchanted the most meme-worthy and vanilla cards. Among the gold cards, I'm missing the Commander's Blade (Frontguard, Leonid, Charlotte), Uriel, Blood Moon, and various minor meme cards, but I don't have three copies of all the good gold cards – for example, I only have one Genesis. And I also don't have Anika, which is a shame; I have two copies of Dovakhin, though.
The situation is even worse with legendaries. I don't have Minty (and I'm not particularly interested in her, to be honest), Tia (I'll probably craft her eventually, but I'll see), Belfi (she's in 95% of blood decks, so it's not cool not having her), Syvil (sad face), Cerbi (very sad face), Beast Dominika (and I'm not particularly interested in her (2)), Fairy Princess (and I'm not particularly interested in her (3)), Sotsubaki (it's a shame, I can't make a decent mid-range sword deck), Fortoche (she's actually my first candidate for crafting, but I still won't have enough dust for the Jack Dragon), Mouse Queen (it's a pity, she looks like one of the best blood legendaries), Gabby (50/50), Roland (I can only dream of a control sword deck), Pluto (and I'm not particularly interested in her (4), but I do have a spell for her), Mithril Golem (and I'm not particularly interested in him (5)), Dragoon (it's bad), Aegis (that's why I'm using Guardian Seitan, lol), and Bahich (in my defense, my best decks don't require me to include three copies of him, and I don't have enough dust for the rest even without Bahich). And I don't have three copies of all the necessary legendaries.