I don't clean up at all. Everything is methodically organized into folders.
The first one (the smallest - 50 GB) is, of course, the operating system.
The second and third are 450 GB each.
One is terribly full, a complete mess. It stores pictures, music, most of the games, and all sorts of random files.
The other is a sanctuary. Two folders - Games and Video. In "Games" there are only two folders - Resident Evil (a total of seven games, four movies, a ton of pictures, soundtracks, and Wesker's Report) and Dragon Age: Origins.
In "Video," as you can guess, there's all sorts of video, from clips to entire seasons of various TV shows (Friends, Heroes, South Park, etc.).
Everything is neat and tidy.
Revan, you forgot about the others) or there's a lot of space in your heart