Nowaru

No, there can be situations where maps, in one way or another, disrupt a character's entire storyline, and it becomes unclear what they should do next... For example, Koshi Nuesh became a family man. You can, of course, force him to return to a life of adventure, but that will depend on the specific role-playing – in general, he is not obliged to return to expeditions, which means it is logical to create a new character.
Another question is, if a character suffers something like blindness in one eye, then this is not a very good reason to end their story. Saburo clearly showed that this is not the end.