It’s complicated; I usually replace effects if I need to change something and there isn't an obvious solution.

For example, what is “Lay on Hands” for me? It’s a flash on the palm, swirling particles, and possibly a general glow before the flash.

You can take the flash from the Thunderstorm spell or try taking the end of a portal into the city – this is a glow ending in a flash.

A vortex of particles is simply a teleport or whirlpool.

Everything can be attached to the elbow and hand bones, and you can create a new effect.

To orient yourself with the axes, take an XYZ axis model and attach it to a bone /topic/15244/.

To rotate an effect, you usually just need to know that a 90-degree rotation is 0.707 along the rotation axis and 0.707 in W. To perform a complex rotation across multiple axes, you will have to "simulate" the rotation in Blender. There, you can select the "Quaternion" rotation mode, and instead of XYZ angles, there will be wxyz values corresponding to the angle from the particle instance.