You'll have to choose between "withering flame" and "fire wrath," and you won't be able to take both. And in general, good skills that complement each other often can't be taken together... :confused:
A pleasant exception is the demon ballista – it's all good, both the rapid-fire ballista and the fire arrows... (it's just a shame there are no rune machines :D although in the new game, that wouldn't seem unusual)