Ple-Sen
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It seems to me that if the beam has any checks, they would be against reaction or speed. And yes, it's possible with negation. Just keep in mind that for such checks, Carvelos's willpower will be 62 or even higher (due to his equipment). The situation is similar with paralysis checks, but due to immunity (and this is if the Sylvan ability doesn't double willpower or if he doesn't have items that grant immunity to paralysis). At the same time, even if his HP drops to two-thirds after your successful black holes, his accuracy, willpower, speed, reaction, and number of attacks will increase. He will resist your attacks even better and inflict such a barrage of blows that he will fully heal and raise his stats even higher through ecstasy.