The theory of evolution, for example, did not raise any questions 50 years ago, although Darwin himself questioned his own work.
In principle, this can be said about any phenomenon. When we talk about history, for example, we operate with "facts" recognized by historical science, although we have never seen them ourselves. But here's the paradox - any historical fact can be questioned, in the same way that the theory of evolution was eventually questioned. This, in my opinion, proves that knowledge of the unseen is conditional.
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"So much has gone
and little is new"
David Bowie