A karate practitioner has an advantage – their legs. BUT! in a street fight, there will inevitably be contact sooner or later. It won't be a problem for a wrestler to put the opponent on their back. (Hip throw, back arch, leg sweep – there's a whole range of options:D)
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A judoka has reactions to both hands and legs (this is developed through grappling). So, you can catch a leg or an arm and do something with it:D