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A group of Japanese researchers has successfully created a miniature liver from human stem cells. Pluripotent cells were transformed into a 4-millimeter diameter disc, which proved its functionality after being transplanted into the body of a laboratory mouse with a malfunctioning liver. The details of the study are published in the journal Nature, and Nature News provided a brief overview.
The researchers used induced pluripotent stem cells, meaning stem cells obtained by reprogramming mature cells from an adult human. They then managed to transform them into both hepatocytes and cells of blood vessels and connective tissue, resulting in a three-dimensional structure. Histological analysis revealed the presence of all the necessary elements for a liver.
The transplantation of the miniature, approximately four-millimeter diameter discs, grown in a laboratory, into laboratory mice demonstrated the functionality of the artificial liver. Two days after the operation, the animal's blood vessels connected with the liver's vessels, and the cells continued to divide, causing the organ to continue growing. The liver is known for its high regenerative capacity, so patients who require a new liver are often transplanted with a small part of the organ taken from a living donor.
It is still too early to talk about the imminent introduction of liver transplants from stem cells into clinical practice. The researchers intend to first observe the behavior of the artificial liver in the mouse's body to ensure its safety and stability. Some previous scientific studies have shown that induced stem cells more often transform into tumor cells, so it is first necessary to ensure that the new liver can limit its growth and maintain the required functions.
Although liver transplants are well-established and patients can return to active life after them, they cannot be considered a routine and readily available procedure: immunological limitations make it difficult to find a donor. To solve the problem of organ shortage, scientists are currently working in several directions: some groups are trying to assemble a liver from ready-made cell cultures (such a liver has already been printed on a 3D printer), while others are trying to repeat the process of forming an organ from stem cells from scratch.
The researchers used induced pluripotent stem cells, meaning stem cells obtained by reprogramming mature cells from an adult human. They then managed to transform them into both hepatocytes and cells of blood vessels and connective tissue, resulting in a three-dimensional structure. Histological analysis revealed the presence of all the necessary elements for a liver.
The transplantation of the miniature, approximately four-millimeter diameter discs, grown in a laboratory, into laboratory mice demonstrated the functionality of the artificial liver. Two days after the operation, the animal's blood vessels connected with the liver's vessels, and the cells continued to divide, causing the organ to continue growing. The liver is known for its high regenerative capacity, so patients who require a new liver are often transplanted with a small part of the organ taken from a living donor.
It is still too early to talk about the imminent introduction of liver transplants from stem cells into clinical practice. The researchers intend to first observe the behavior of the artificial liver in the mouse's body to ensure its safety and stability. Some previous scientific studies have shown that induced stem cells more often transform into tumor cells, so it is first necessary to ensure that the new liver can limit its growth and maintain the required functions.
Although liver transplants are well-established and patients can return to active life after them, they cannot be considered a routine and readily available procedure: immunological limitations make it difficult to find a donor. To solve the problem of organ shortage, scientists are currently working in several directions: some groups are trying to assemble a liver from ready-made cell cultures (such a liver has already been printed on a 3D printer), while others are trying to repeat the process of forming an organ from stem cells from scratch.
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И пока в кармане пачка милкиуэйев - значит все не так уж плохо на сегодняшний день
И пока в кармане пачка милкиуэйев - значит все не так уж плохо на сегодняшний день