Should I take the Wisdom skill?

As I understand it, the more Dragon Utopia there is, the fewer arguments for Wisdom; the more Pandora's boxes, the more arguments for Wisdom.

Yes, but not only that. It's important how many resources can be gathered to build the guild and how quickly the hero is leveled up.

BUT! The game is played with random maps! That means we cannot know in advance how much Dragon Utopia or Pandora there will be...

We can. It depends on the template structure. In some places, relics and Dragon Utopia aren't generated at all.

For now, I suggest speaking out on the following issue: 2sm4d3, SoD, do we take Wisdom?

By default, of course not. We take it in these cases:
1. Two starting skills were experted, and nothing better was given at level 6
2. A lot of resources accumulated by the end of the first week, there is an opportunity to place Mage Guild from 121 and finish building it during the second week (which is not insignificant). Also artifacts for knowledge/power. If only 1 knowledge, then there is no point at all.
3. The game is prolonged, nothing useful was found, and main skills are already leveled up.

Wisdom is given every i+5 level, so you can take Wisdom without rushing. Also, there's no point in taking Wisdom if we have a bunch of basic skills, meaning it's unclear when we'll manage to level up Wisdom.