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I don't know how it is in duels. But in Inferno battles, they should beat Necropolis. Inferno has higher initiative and develops its city faster, and its skills are better too :) IMHO. And then just use your brain. That's why Sanctuary almost always remains last in battles, because they even have more initiative than Inferno.
But in general, Sanctuary is even more interesting. Plus, their heroes have ideal starting skills: explorer, master of ice block, gladiator, lumberjack, master of ice armor, the highest initiative. Sanctuary should be easy to play on a normal difficulty level :) If Inferno had such heroes, and Necropolis would be in trouble :) IMHO.