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Basically, we need a mix of Fallout, Diablo, and BG/Icewind Dale/Neverwinter Nights.
And games in the 3rd and 1st person should remain for single-player experiences; they work better that way.
I remember taking an elf fan with me in Oblivion. Every time we fought, he would run off to who knows where, and some of the mobs would follow him. Once, I found him on the rocks near a waterfall. Poor guy fell to his death.