Orcs vs. Humans

Lordesat so what will you take if not anti-darkness?
If not a placeholder, I think luck and some reflection skills would be good... or does anyone else have any ideas?

The only thing that can be used against darkness, as I've said many times, is magic resistance and goblin tricks. Only with this setup can you hope for something. But taking a darkness-nullifying skill in the late game is useless. It only works well up to level 20.
A light-nullifying skill in the late game is a better idea, but it works well, for example, against Divine Retribution. So, it's best for an Orc to go into the Sanctuary and take artifacts and skills that increase magic resistance, meaning luck is a must.