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It turns out that Dyrael is a good match against Karl. I tried having Karl use magic resistance runes, but you can miss with the element, and in general, it doesn't work against an experienced opponent. I tried having Karl use lightning runes at the beginning, but that might not work either, and it didn't. Dyrael overwhelms Karl with her power, although maybe I wasn't playing Karl correctly, but I still feel that there are some interesting dynamics in this matchup.