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The most important thing that developers should have when creating the 6th installment of the Heroes series is NOT focusing on mass appeal. They should have the freedom to create what they believe is right. Not everyone is ready to accept something new, but if they are afraid to show this new thing, then... well, nothing good will come of it.
P.S. By the way, there is nothing new in the 5th game. It takes everything from the previous parts and develops it, which is good, of course, but it's a direction towards being more mainstream.
P.P.S. I have a positive attitude towards the 5th game =D