I wouldn't say that shackles are a good thing... It's an artifact with a catch, and it might even be detrimental, so I approach it with some distrust=))
But in my opinion, the golden bow, for example, and the sphere of prohibition are good=)) (I'm not talking about the Grail and the blade, as I consider them to be comparable in power, and after them, the game is basically pointless, IMHO).
And the best artifact is the one that helps me win - even a chain of gnolls, etc. - will do.