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Are you just kidding? Some players from the original lineups haven't participated in the tournament for a long time, and our brackets look like this:
1. Lizard - Lucky
2. Caliban -
3. - Mike
4. Matador - Alfein
5. Frisha - TT
6. Shrek -
Ideally, brackets without players should be automatically removed. That is, only 3 brackets are involved: 1st, 4th, and 5th. If I'm wrong, please clarify how it should be.
However, I don't see any particular difficulties – you can choose which brackets to remove, so just remove the brackets where you don't have players.
If anything, the one-sided substitution rule still applies.